The highway D400, which traverses through major cities and towns of the region, and 8-lane motorway/toll-road O-51/O-52/E90, which lies a few km north of D400 and thus bypassing the cities and towns, form the backbone of local traffic.
However, due to the reports of banditry on quite desolate O-51/O-52, especially in the section between Adana and Osmaniye, drivers are advised not to stop even on the orders from someone seemingly police or to help what is seemingly an accident on the edge of the road, as these are usual tricks known to make drivers stop and easily rob them of valuables.
Fairly frequent and modern best of all, air-con trains connect Mersin with Adana, also calling at Tarsus, the other major city of the region, and Yenice, town with the station on the national rail network, on the way. Services east from Adana towards Toprakkale and Osmaniye are spotty at best, with seemingly vintage passenger cars dating back to 1950s.
