There are direct buses from San Pedro Sula and Guatemala.
Elsewhere in Honduras: There are regular shuttle buses to Copán Ruinas L40 from La Entrada, a regional transport hub about 1-2 hours from Copán. Find a bus that passes through La Entrada San Jose, San Pedro Sula, Nueva Ocotepeque, etc..As from 2012 air viva offers regular flights from Copán to Roatan and Tegucigalpa.
Hedman Alas (http://www.hedmanalas.com/) services Copán Ruinas from San Pedro Sula, with connections to/from Tegucigalpa, La Ceiba, and elsewhere. If you just go to the San Pedro Sula bus station, it's likely a bus will be leaving in the near future. Casasola Expresses is a budget L110 alternative to Hedman Alas.
Guatemala: There are daily shuttles that depart Antigua, Guatemala at 4AM and 9AM and arrive in Copán Ruinas around six hours after departure time. Most travel agents in Antigua sell tickets for this shuttle. Prices vary from $7 to $12.
El Salvador
Cross the border at El Poy. From there you can get a share taxi to Nueva Ocotepeque L20. Board a San Jose bound bus and get off at La Entrada L90. There you can find a minibus to Copán Ruinas L40.
There is a direct shuttle service that depart several days every week at 12:30 p.m., tickets can be purchased in Cafe Via Via or online at www.gekkotrailsexplorer.com, there are several arrival places in El Salvador Santa Ana city, Suchitoto, San Salvador city, Beaches El Tunco, San Diego, El Sunzal, el Zonte.
