By plane
The main airport servicing the area is Williamsport Regional Airport IATA: IPT, ICAO: KIPT, located in nearby Montoursville. Options are extremely limited, with only one destination served: US Airways flies to their hub in Philadelphia. Because US Airways has a monopoly on the airport, flying to Williamsport can be an expensive endeavor.
By car
Williamsport is connected to two Interstates: I-180 and I-99. I-80, which terminates at Interstate 80 south of Williamsport, is the road you'll use if you're coming from New York or Philadelphia. From Pittsburgh, you'll use I-99, which is not entirely completed and still has some non-expressway gaps, so expect construction and some confusion. You might spot signs saying "Future I-99 corridor" on the drive in. Points north should use US-15, which will one day be I-99. The area north of Williamsport is sparsely populated though, so there will probably be little in the way of delays, just a rather scenic mountain drive.