by plane
Quincy is served by Quincy Regional Airport-Baldwin Field, to the east of the city. It is easily accessible from the city center by going east on Illinois Route 104 Broadway St..
by car
If coming from St. Louis, you can take I-70 west towards Kansas City. At exit 210B, take the ramp right for US-61 North towards Hannibal. Stay on US-61, and in Hannibal, take the ramp right for I-72 East / Mark Twain Avenue East towards Springfield IL. / Downtown Hannibal. At exit 4B, take ramp left for I-172 North towards Quincy. Get off at exit 14, Broadway St., to get to the center of town. This trip takes roughly two and a half hours with traffic.
If arriving from Chicago, take I-55 / Stevenson Expressway towards St. Louis. At Springfield, keep right and stay on I-72 West. Keep straight onto I-172 North. This trip takes about four and a half hours with traffic.