There are three main roadways that serve the town: Lewis & Clark Pkwy formally IN 131, Eastern Blvd and Veterans Pkwy. Lewis & Clark is the main drag through the town, running southwest to northeast connecting Browns Station Way near New Albany with I-65. Eastern Blvd runs southeast to northwest connecting I-65 in Jeffersonville with Lewis & Clark. The newer Veterans Pkwy built in 2004 runs along the northern end of town, connecting Greentree Blvd with the north side of Jeffersonville.
Other roadways serve Clarksville. Browns Station Way formally IN 62 is a limited access highway that cuts through Clarksville, connecting I-65 with the east end of New Albany. Greentree Blvd runs along the east side of Greentree Mall and connects the mall with Veterans Pkwy. Riverside Dr. runs along the Ohio River between Clarksville and Jeffersonville. Stansifer Ave, in the southside of town runs between Jeffersonville's Spring St. and Clarksville's west end.
Louisville's TARC offers bus service along the main roadways and shopping centers.
