Interstate 65 connects Jeffersonville with Louisville and other points between Chicago and Mobile, AL. Indiana 265 soon to be Interstate 265 when a new bridge to Kentucky is opened in the 2010's offers a bypass around the northern end of the city.
Small aircraft can fly into Clark County Airport, five miles north in Sellersburg. Passenger jet service is available at Louisville International Airport, eight miles south off of I-65 and I-264.
Amtrak discontinued service to Jeffersonville and Louisville in 2003.
