The two main routes into Houghton and Hancock from the south are US-41 and M26.
Travelers coming from Green Bay or the central or eastern Upper Peninsula will likely travel on US-41. You'll know you've arrived because you'll suddenly find yourself surrounded by large modern university buildings, sprawling parking lots, and fraternity houses; you're on the campus of Michigan Tech. Keep driving to reach downtown Houghton, where the architecture transforms into old red sandstone buildings lining the tightly-packed small town business district overlooking the canal. US-41 then crosses the lift bridge into Hancock, which climbs the ridge on the north side of the channel.
Those arriving from central Wisconsin, Minnesota, or the Western UP will take M26. The first thing you will see will be the Walmart on the right, and an eroded cliff on the left. Like US-41, M26 crosses the lift bridge.
Houghton County Memorial Airport, (http://www.houghtoncounty.org/), has a few flights each day from Chicago although they tend to be fairly expensive. The airport is located about 5 miles north of Houghton/Hancock. To get to Houghton, there is an Avis car rental on-site and Neil's Cab service is also an option.