By plane
Jefferson City Memorial Airport (http://www.jeffcitymo.org...), located just across the Missouri River, only serves general aviation.
The closest airport with commercial service is Columbia Regional Airport (http://www.flymidmo.com/), from which US Highway 63 goes straight to Jefferson City. Delta Air Lines (http://www.delta.com) is the only carrier at the airport, with service from Memphis.
The closest full-scale commercial airport is Lambert St. Louis International Airport (http://www.flystl.com/), about two hours away. It is very easy to get from the St. Louis airport to Jefferson City. Take I-70 west out of St. Louis for about an hour and a half. At this point take US Highway 54 south for about thirty minutes until you reach Jefferson City.
A little further is the Kansas City International Airport, about three hours away.
By train
The Amtrak Station is located right downtown at 101 Jefferson Street. At the mid-point of the Kansas City to St. Louis route, the Missouri River Runner www.missouri-river-runner.com, there are two departures each direction every day. While a ticket is not needed to board the train, a reservation is. Call 800-USA-Rail or visit (http://www.amtrak.com) for reservations and schedule information.
By car
Jefferson is centrally located in the State of Missouri about half-way between St. Louis and Kansas City along the Missouri River. There are three major highways that run directly through the city: US 50, 54, and 63.