Holmes County is accessible from: I-71, I-77, and US 30
State Route 83 running north and south from US Route 30 in Wooster, through Millersburg, to US Route 36 and 16 in Coshocton.
State Route 39 running east and west from I-77 in Dover, through Walnut Creek, Berlin and Millersburg, exiting the west side of the county in Loudonville toward I-71.
US Route 62 running east and west from I-77 in Canton, through Wilmot and Winesburg, on to Berlin and Millersburg, exiting the southwestern corner of the county toward Columbus.
