Interstate 275 provides the quickest access to Clermont County from Northern Kentucky and Hamilton County.
U.S. Route 50 connects Annapolis, Maryland to Sacramento, California via Clermont County. U.S. Route 52 follows Clermont County's southern border along the Ohio River. U.S. 52 connects Charleston, South Carolina with Portal, North Dakota.
State Routes 32, 125, and 131 also connect many Ohios towns and cities. State Route 32 connects West Virginia with Cincinnati and runs throught the mid-section of Clermont County.
