The Stone Cellar Brewpub (http://www.stonecellarbre...) brews several standard beers, plus seasonal beers. They also have a wide variety menu selections and a great atmosphere in the cellar of Appleton's first brewery built in 1858, or if the weather cooperates you can sit outside in the beer garden.
On St. Patrick's Day, or any day if you're Irish, be sure to visit McGuiness Irish Pub (http://www.mcguinnessiris...) or The Durty Leprechaun.
If you're staying downtown at the Radisson Paper Valley Hotel and you don't feel like venturing far, The Clubhouse just off the lobby has plenty of beer, sandwiches, pizza and 20 big screen TVs.
For visitors staying at AmericInn or Cambria Suites on the northeast side of town near Thrivent Financial and USA Youth Soccer, Beefeaters (http://www.beefeaterspub.com/) has a great British pub atmosphere and good food.