The usual comments on driving in the Great Plains apply. This is a good area in which to keep your gas tank full; towns are few and far between, and you don't want to run out of gas forty miles from nowhere. There is very little crime after all, there's very little population and no public health hazards of any unusual significance.
talk
Mainly to yourself; this is a very empty region. Non-English speakers are in shorter supply than in some other areas of New Mexico, but you may have some opportunities to use Spanish, particularly in some of the small towns near the Sangre de Cristos where Spanish may even be the dominant language.