Ozona

This is about the only way you'll find anything worth more than a few minutes.

Big Bend National Park (http://www.nps.gov/bibe/)

Seminole Canyon State Historical Site
(http://www.tpwd.state.tx....)
Fort Lancaster State Historical Site
(http://www.tpwd.state.tx....)

Kerrville - a few hours east, with history and personality