Suehiro-cho in the downtown area is the nightlife center of Kushiro, with many Japanese-style bars izakaya, restaurants, karaoke boxes and snack bars bars where female hostesses entertain guests condensed in a few blocks. Most bars have a cover charge of 500 yen and one alcoholic drink generally costs the same.
Kushiro has its own beer brewery, which produces some interesting concoctions like salmon ale. However, bars generally do not sell the local brew, so you should look for them at a dedicated alcohol shop.
Another local drink is Tantakatan, a shochu made with shiso leaves grown in the Shiranuka area 40 minutes west of Kushiro.