By car
By car
Manisa is on the main Istanbul–Balıkesir–Izmir highway, numbered D565, as well as the main Izmir–Ankara highway, D300.
By bus
By bus
Manisa lies on the main route Istanbul–Izmir buses take, so has a very high frequency of bus connections from those cities, as well as from Balıkesir and Bursa, both of which also lie on the same route.