Matt and Phred's
Good little tucked away jazz club! Also serves up good pizza. They have jazz bands every night except Mondays when it's closed at 10PM. There is free entry before 8PM. If you want to enjoy the jazz seated, seats have to be booked at least a few days beforehand.
Night and Day Café
The venue to see bands before they make it big! Bands such as Oasis and Badly Drawn Boy have played here. Well worth a visit. Can be a little bit pokey inside, as it's not the biggest venue!
KRO Piccadilly
Flash Danish bar right in the heart of Piccadilly Gardens. A lot less student-y and pricier than the other KRO bars in Manchester, and has a good selection of European premium lagers and great food.
Essential
Poptastic
Manna Manchester
Nice little café with friendly staff located on the edge of the landscaped garden. Serves good coffee, sandwiches, drinks, and sweet things. Everything here is both Fair trade and organic, so feel good when you go there!