As with most other large English cities, there can be a problem with violence around the city centre at weekends, around pub and club closing times around 11PM and 2AM, but with a little common sense, the risk is minor.
The main place to avoid is Somerstown, the highrise council estate near the city centre, especially after dark.
Nothing should be left on display in vehicles and it's sensible to park your car in a Park Marque scheme facility ask at the Visitor Info Centre +44 23 9282 6722.
Due to football rivalry, wearing a Southampton football top may cause some problems in the city. In fact, anything with red and white vertical stripes Southampton's colours is probably a bad idea.