There are several night clubs in Ayr. Arguably the largest of which is Club de Mar. Another, Madisons, is popular with the 18-30 crowd. There is also a Fury Murrys in Ayr which caters to the more rock/metal side of the musical spectrum. All are located in Ayr town centre.
Ayr has many bars, the most mainstream of which located in the vicinity of the Bus Station.