The West End is easily accessible from the Central Business District. Heading west on almost any of the streets from downtown will lead you there. The main thoroughfare is West Georgia Street, which runs through the neighbourhood to Stanley Park and into the North Shore via the Lions Gate Bridge. Robson Street and Davie Street are also busy streets that carry traffic between the West End and the rest of downtown.
By car
If you are driving, it is best to park your car and explore the area by foot. Many of the side streets are traffic calmed in some manner and are frequently blocked off so they cannot be used for through traffic. Parking lots are available in Coal Harbour $12-$15 for the day and Stanley Park. There is also limited on-street parking in the residential areas.
By bus
The West End is mostly serviced by Translink (http://www.translink.ca) buses from the Central Business District. If travelling from other parts of Vancouver by public transit, you will have to get downtown first and then board one of the following:
#5 - heads to English Bay via Robson Street
#6 - heads to English Bay via Davie Street
#19 - ends in Stanley Park with connections downtown and at Metrotown in Burnaby
If travelling from the North Shore, the following buses pass through the West End on their way downtown:
#240 - connects with the Central Lonsdale area of North Vancouver
#250, 251, 252 - connects with various parts of West Vancouver, via Park Royal Mall