Understand
Truth be told, the 'rough' reputation that South San Francisco has is nowadays mostly undeserved. The first thing you'll notice is a gigantic sign on the hill between South SF or as the locals say, "South City" and Brisbane which reads in block capitals: "SOUTH SAN FRANCISCO THE INDUSTRIAL CITY". Yes, it is industrial, but not so much anymore. Mostly what that means is there are a bunch of warehouses and train tracks in the southeast corner of South City, and whoops now you're at the airport.
The people of South City seem to be broken down ethnically into thirds, with a third being Pan-Asian Chinese, Japanese, and a sizable Filipino population - see Daly City for more, a third being Mexican/South American, and a third being white folk with a concentration of Italians.
Weatherwise, South City is on the cusp between fog and sun. Sometimes the fog is carved off by the mountain between South City and Pacifica, but other times it continues on through and keeps things cool. It can get windy in the hills any time of year.