The major interstates of Oklahoma include:
Interstate 35 connecting Wichita, Kansas and Dallas, Texas via Oklahoma City.
Interstate 40 connecting Fort Smith, Arkansas and Amarillo, Texas, also via Oklahoma City.
Interstate 44 connecting Joplin, Missouri and Wichita Falls, Texas via Tulsa and Oklahoma City.
Also:
Historic US Route 66 closely parallel to I-44 between the Kansas state line to Oklahoma City and I-40 from Oklahoma City to the Texas state line.