On foot
If you are within walking distance of the East Village in decent weather, walking to the neighborhood is the most interesting way to go, and certainly the best way to get around.
By Subway
The best subway line for getting into the heart of the East Village is the 6 train, which stops at Astor Place, just one short block from St. Marks Place. You can also get out at Bleecker Street for more southerly East Village locations between Houston and 4th Streets.
The N and R trains run under Broadway along the western edge of the neighborhood, stopping at 8th Street NYU station near Astor Place.
The L train is a rare crosstown train that runs along 14th Street, the northern edge of the East Village. The 3rd Avenue and especially the 1st Avenue stations can save you some steps if you're headed for more northerly or easterly destinations. The L can also take you to Greenwich Village or Brooklyn's Williamsburg, for a tour of Bohemias past and present.
There are also trains that run along the southern edge of the neighborhood, under Houston Street - take the B, D, F, or M to the Broadway-Lafayette station. The F also runs to the 2nd Avenue station.
There are many trains that stop at Union Square, which is just past the northwest corner of the East Village - but it's something of a hike to the center of the neighborhood. Take the 4, 5, 6, N, Q, R, or the L.
By bus
Numerous MTA bus routes serve the neighborhood. Of particular note, however, are the crosstown buses. The M8 travels east on 8th St., then turns north on Av. A and travels on 10th St. the rest of the way. The M8 travels west on 10th St. and then starting on Av. A, on 9th St. The M14 14th St. crosstown is also notable because after going crosstown on 14th St. from the west side, the M14A bus turns down Av. A, whereas the M14D turns down Av. C and travels down Av. D starting at 10th St.
By taxi
There are usually many taxis in the East Village. It is easiest to flag down a cab on avenues, rather than side streets, but if you are on a side street, look for cabs, anyway, while you walk toward an avenue. Be warned that at peak times and in bad weather, it can be hard to find empty cabs.
By car
Parking in the East Village can be difficult. If you plan to park on the street, be patient and opportunistic, and take care to observe posted parking regulations and avoid parking in front of houses of worship and funeral homes, lest your car should be ticketed or towed. There are also some parking garages in the neighborhood, if you don't mind paying.
By bike
This is absolutely the best way to catch all of the East Village action. If you are coming from uptown on the West Side, take the West Side Green Path down to 14th Street. Cross east on 12th, or any street with a bike lane that runs east! If you are coming down from the East Side, there is an East Side bike path that is interrupted by the United Nations. Simply cross over to Second Ave. and ride south until you cross 14th St.