By Subway
There is plenty of subway service to this area. The 4, 5, and 6 lines travel under Park Avenue south of Grand Central Station and Lexington Avenue north of Grand Central, stopping at 42nd St. Grand Central Station and 59th St., with the 6 also stopping at 51st St. Running under 6th Avenue are the B, D, F, and M lines, which stop at 34th St. close to the Empire State Building, 42nd St. at Bryant Park, near the library and 47-50 St. station near Rockefeller Center. The F line continues up 6th Avenue, stopping at 57th St., while the E and M lines head under 53rd Street, stopping at 5th Av. and Lexington Av. a passageway offers a free transfer to the 6 line. The 7 and S Grand Central Shuttle lines run under 42nd St. Both of them stop at Grand Central Station, with the 7 also stopping at 5th Av. free transfer to the B, D, and F lines. Also serving the neighborhood are the N, Q, and R lines, which stop at 34th St. and 6th Av., close to the Empire State Building.
By Mta Bus
Regular MTA buses run along every avenue except for short avenues like Vanderbilt, and there are also crosstown buses on 34th, 42nd, 49th/50th, and 57th Sts. In addition, express buses stop along these avenues, including the X25 to Lower Manhattan. Express buses charge a $5 fare, with free transfers available to other routes, and local buses charge $2.25 and enable free transfers to other local routes and the subway, with some exceptions.
By Metro North Commuter Train
Metro North commuter trains originate and terminate at Grand Central Terminal on E. 42 St. between Vanderbilt and Lexington Avs. See the By train section on the main New York City page for more info. Note that the train terminal but not the subway stop serving it closes from approximately 1AM to 5AM daily.