The SL4 and SL5 routes of the Silver Line bus rapid transit service make several stops in the South End:
Green Line: The Arlington and Copley stops are a couple blocks north of the border between the Back Bay and the South End.
Orange Line: The Back Bay and Massachusetts Ave. The New England Medical Center stop is slightly farther north.
The Back Bay station is served by Amtrak trains, and by MBTA commuter rail Attleboro/Providence, Framinghham/Worcester, Needham, and Franklin lines.