If you are flying to the area, you are most likely to fly into Burlington International Airport in Burlington. There are smaller state airports closer to Waitsfield, however. Those include Edward F. Knapp Airport in Barre and and Morrisville-Stowe State Airport in Morrisville.
For getting in by car, the closest major interstate is I-89 which stretches from Concord, NH, to Burlington. Waitsfield lies on Vermont Route 100, a scenic and winding road that connects the northern and southern ends of the state. Waitsfield is about 10 miles south of I-89 at Duxbury, Vt.