By car
Durham is served by Interstates 40 and 85, and US routes 15, 501 and 70 along with several state routes. "The Durham Freeway" generally refers to NC-147, which connects I-85 and 15/501 in northwest Durham to I-40 and Research Triangle Park in southeast Durham, by way of downtown. If you wish to rent a car, car rental options at the RDU airport are plentiful and range from $20 to $50 per day, with whole-week rentals significantly discounted.
It should be mentioned that like Atlanta's infamous "Peachtree", Durham has a number of synonymous roadways, in some cases miles from each other. This can easily confuse visitors. The most notorious is Chapel Hill Rd/St/Blvd. The road goes from the city's Lakewood and West End neighborhoods to the Chapel Hill border via Shannon Plaza and the fringe of the South Square area. Mostly residential. The St acts as an arterial from downtown through West End, serving as a vibrant thoroughfare for the neighborhoods in between. "The Boulevard" as it is known in the neighborhoods surrounding it, courses from the foot of the Forest Hills neighborhood and bee-lines directly west to Chapel Hill, eventually becoming 15-501. Mainly commercial with lots of big-box retailers and chain restaurants. When in doubt, ask a local!
Parking is plentiful in Durham, even in the more populous areas. Be mindful of parking in residential zones in the city for extended periods without a permit.