Fast motor launches leave Manaus in the early morning. 10 hours, 120-150 reais, two different comanies on alternating days.
Several large riverboats a day from Manaus, about 30 hours.
Two boats a day to Santarem, 14 hours, 50 reais. These are en-route from Manaus, often with delays.
Trip (http://www.voetrip.com.br/) flies to many regional destinations.